Endocrine Abstracts

Aim: To study the results of transsphenoidal surgery in our Neuroendocrinology Unit in last 10 years.Methods: We reviewed all patients operated in our hospital and followed in our Neuroendocrinology Unit in the last 10 years. We excluded patients with previous surgery or irradiation on this area. We obtained data about type and size of tumor, previous hormonal deficit, local symptoms,complications of surgery and the status after this (remission, persiste...

Aims: To know characteristics and long term evolution of patients with prolactinoma in our Neuroendocrinology Unit.Material and methods: We studied retrospectively all patients with diagnosis of prolactinoma in our Neuroendocrinology Unit in last 12 years.Results: We studied 126 patients. Predominant sex was female (69.07%), 56.7% were macroadenomas. The time from the onset of symptoms until they are seen by the specialist ranges 1...

Introduction: The recombinant GH receptor antagonist pegvisomant (PGV) is actually used for the treatment of acromegaly when surgery and medical therapy with somatostatin analogues (SSA) have failed. Long term safety and effectiveness need to be evaluated.Material and methods: Retrospective analysis of clinical data from all patients treated with pegvisomant in a pituitary disorders unit.Results: Thirteen patients are being treated...

Objective: To report a case of hyperandrogenism attributable to the presence of an ovarian Leydig cell tumor secreting testosterone in a postmenopausal woman.Methods: The laboratory, radiologic, and pathologic findings in our case are described.Results: A 59-year-old woman presented with a history of gradual increase in facial and body hair, scalp hair loss, male pattern baldness, and deepening of her voice, beginning 5–6 year...

Background: Vitamin D deficiency is an important public health problem because of its great impact on bone metabolism and the possible implication in cardiovascular outcomes, diabetes, cancer and mortality. Cross-sectional studies have related vitamin D deficiency with the prevalence of diabetes but there are only a few prospective cohort studies on the incidence of type 2 diabetes.Objective: To investigate the relationship between levels of 25-hydroxyvi...

Introduction and objetives: There are few data in literature about the effects of rosuvastatin in patients with familial hypercholesterolemia in Spain. The objective of this study has been:1-to evaluate the efficacy and security of rosuvastatin in patients with familiar hypercholesterolemia2-to test the hypothesis that patients with diabetes have different response to treatment with rosuvastatin.Material and ...

Introduction: Patients with bariatric surgery require close monitoring because of possible metabolic complications. It has been published some cases of severe and persistent hypoglycemias resistant to diet and pharmacologic treatment being necessary a pancreatectomy. We present a case report of nesidioblastosis after gastric bypass that required subtotal pancreatectomy but despite this, hypoglycemias persisted. Before performing total pancreatectomy we placed a tube feeding in...

Introduction and objective: The pregnancies in women with pregestational diabetes are associated with increased risk of abortion, birth defects, complications of pregnancy and perinatal morbidity and mortality. Pregnancy planning would be associated with better metabolic control, and therefore better obstetric and perinatal outcomes. The objetive of this study has been to evaluate the obstetric results of women with pregestacional type 1 diabetes and compare planned with not p...

Objective: Calculation of accurate insulin boluses is one of the major problems related to intensive insulin regimens. A bolus calculator (BC) incorporated into the insulin pump estimates the dose of insulin to be administered at the meal and makes calculation easier and more precise.The aim of the present study was to assess the efficacy of a BC on glycaemic control of patients with DM1 on CSII.Material and methods: We enrolled 20...

Objective: To evaluate the effects of GH on cardiac structure and function of patients with panhypopituitarism.Material and methods: We performed echocardiographic studies of patients with panhypopituitarism treated and not treated with GH at baseline and after 12 years of follow up. We collected clinical and echocardiographic data (systolic and diastolic ventricular diameter (LVEDD and DTSVI), interventricular septum thickness (IVS), left ventricular po...